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Formula
C10H8BrN5OS
MW
326.18
Purity
>97%
Solubility (DMSO Mg/MI)
60
Bio Chemical Notes
Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 ?M in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitro and in vivo. Enhances the antitumor activity of temozolomide (Cat. No. 2706) in both human melanoma and MCF-7 xenografts.