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Product Details
Formula
C19H20F3IN2O5S
MW
572.34
Purity
>95%
Solubility (DMSO Mg/MI)
90
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
N/A
Mode Of Action
inhibitor
Target Name
Mitogen-activated protein kinase kinase 1 (MEK1)/Mitogen-activated protein kinase kinase 2 (MEK2)
Research Area
CANCER
Research Area Sub Group
Anticancer
Pharmacology
ENZYMES
Pharmacology Area Sub Group
Kinase
Bio Chemical Notes
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.